Aim To study the influential factors that lead to form coronary collateral circulation. Methods The date of coronary angiography and clinical characteristics were analysed in 253 cases with coronary heart disease(CHD) underwent coronary angiography [coronary collateral circulation was present in 122 patients (Forming collateral circulation group) and absent in 131 patients as control group(No collateral circulation group). [WTHZ]Results 98.36% of patients in the forming collateral circulation group presented complete or sub total occlusion of coronary artery . The multiple vessel occlusion rate and complete occlusion rate of coronary artery were significantly higher in the forming collateral circulation group than those of the no collaterai circulation group(30.00% vs 11.45%,p<0.001;75.77% vs 60.27%, p<0.05,individually). The rate of forming collateral was higher in the vessels with complete occlusion than those of sud total occlusion(58.09% vs 40.20%,p<0.05). Multivariate logistic regression analysis showed that vassel occlusion number and degree were two significant variables associated with collateral circulation.The level of serum total cholesterol and abnormal rate of serum triglycerin were significantly higher in the no collateral circulation group than those of the forming collateral circulation group (5.03±1.38 mmol/L vs 4.68± 1.06 mmol/L,p<0.05; 45.80% vs 32.78%,p<0.05). Conclusion The serious degree of coronary occlusion lesion is great important factors of whether forming coronary collateral circulation. Hyperlipidemia is not good for the formation of coronary collateral circulation.