Aim To study the association of interleukin-6 (IL-6) gene -572C/G polymorphism with coronary heart disease (CHD). Methods IL-6/-572C/G polymorphism was examined in 139 CHD patients and 168 healthy adults by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results -572CC, CG and GG genotype frequencies were 51.80%, 40.29% and 7.91% in CHD group, 63.10%, 35.71% and 1.19% in control group respectively. -572 G and C allele frequencies were 28.06%, 71.94% and 19.05%, 81.95% in two groups respectively. GG genotype and G allele were more frequent in patients than in controls (p<0.01). Compared with CC genotype, relative risk (RR) for CHD were 1.37 (95%CI: 0.86～2.20, p>0.05) for CG genotype and 2.85 (95%CI: 1.32～6.13, p<0.01) for GG genotype. After adjusting for classical risk factors, the effect of GG genotype remained statistically significant (Rr=2.85, 95%CI: 1.22～6.65,p<0.05). But the distribution of IL-6/-572C/G polymorphism had no significant difference among patients with stable angina, unstable angina and myocardial infarction, among patients with single-vessel,two-vessel and there-vessel lesions too(p>0.05). Conclusions IL-6/-572C/G polymorphism was associated with susceptibility to CHD and GG genotypes might be a risk factor for CHD in Chinese Hans population.