Aim To observe the expression of found in inflammatory zone1(FIZZ1) in aortic atherosclerosis lesion and the interventional effect of rosiglitazone in apolipoprotein E-knockout mice. Methods Eight-week-old apoE knockout mice were divided into atherosclerosis(As) group(n=10) and rosiglitazone group(n=10).Wildtype C57/BL mice(n=10) were used as normal control group(n=10).All mice were fed with normal chow diet.In addition to normal diet,rosiglitazone group received rosiglitazone 10 mg/(kg·g) of body weight.After 12 weeks,aorta were used for histomorphometric analysis of atherosclerosis lesion,immunohistochemistry and RT-PCR for the expression of FIZZ1.Vessel bloods were collected for plAsma lipid and high sensitive-CRP(hs-CRP). Results There is no significant difference in blood lipid level between As group and rosiglitazone group.The hs-CRP level in As group is significantly higher than that in rosiglitazone group.Histomorphometric analysis showed that the area of atherosclerosis plaque in As group was significantly bigger than that in rosiglitazone group.Immunohistochemistry and RT-PCR showed that the expression of FIZZ1 in As group were higher than that in rosiglitazone group. Conclusion The expression of FIZZ1 in atherosclerosis lesion was observed.Rosiglitazone can decrease hs-CRP level,reduce the expression of FIZZ1 in aortic atherosclerosis lesion.It is not related to modulation of blood lipid that rosiglitazone inhibits the development of aortic atherosclerosis.Anti-inflammation is a potential mechanism.