Aim To investigate the correlation and factors of plasma α2-heremans-schmid glycoprotein(AHSG) level and lower extremity atherosclerosis(LEA) in patients with type 2 diabetes. Methods Two hundred and forty five patients with type 2 diabetes and eighty-eight normal controls were enrolled.In these subjects,the plasma AHSG level were detected by enzyme linked immunosorbent assay(ELISA),and the degrement atherosclerosis of lower extremity was examined by Color Doppler Ultrasound,and TC,TG,HDL,LDL,Cr,BUN and fasting blood glucose(FBG) were measured.The differences were compared between the two groups.The effect factors of AHSG level by multiple stepwise regression analysis were defined. Results The plasma levels of AHSG,SBP,DBP,BMI,BUN,Cr,FPG,TC,TG,HDL and LDL and scroces of LEA in the diabetic group were higher than those in the normal control group(P><0.01).After multiple stepwise regression analysis,there was a negative correlation between plasma AHSG level and age(P>=0.011),but there was a positive correlation between LEA and age(P>=0.001). Conclusions The plasma AHSG level in the diabetic group was higher than that in the normal control,maybe mainly due to insulin resistance.The plasma AHSG level had a positive correlation with LEA,but a negative correlation with age.