Cardiovascular calcification happens early and seriously in uremia, of which cardiac valve calcification is relatively common.It can cause not only valve stenosis and (or) incompetence but also arrhythmia, ventricular hypertrophy, cardiac insufficiency, even sudden death, etc.Researches show that many factors were involved in cardiac valve calcification in uremia, such as calcium phosphate metabolism imbalance, parathyroid hormone, vitamin D, inflammation, fetuin-A, etc.Cardiac valve calcification is the imbalance of the results of calcification promoters and inhibition.Its mechnism in recent years is reviewed in this paper.