AimTo evaluate the association of ATP-binding cassette transporter A1(ABCA1) gene R219K polymorphism with coronary heart disease (CHD) in Chinese Han population.MethodsCase-control studies published before 31 May 2012 about the association of ABCA1 gene R219K polymorphism and CHD in Chinese Han population were searched.All the literatures were evaluated and abstracted based on the defined selection criteria by two independent investigators.Publication bias was tested by Egger’s test and the odd ratios of all studies were combined dependent on the result of heterogeneity test among the individual studies.The software Stata (version 11.0 ) were used for Meta-analysis.ResultsA total of twelve case-control studies were collected, 2257 cases and 2356 controls were involved in the Meta-analysis.The results indicated that the K219 was significantly associated with CHD (OR=0.66, 95%CI 0.55～0.80, p<0.0001) under dominant model and (OR=0.63, 95%CI 0.53～0.75, p<0.00001) under recessive model, respectively.No significant publication bias was found.ConclusionsR219K polymorphism in ABCA1 gene is associated with susceptibility of CHD and K allele might be a protective factor for CHD in Chinese Han population.