Aim To observed the efficacy of Escitalopram joint Tandospirone in treating older women patients with coronary heart disease complicating anxiety disorder combined depression disorder.Methods The 100 older women patients with coronary heart disease complicating anxiety disorder combined depressio.disorder selected as the research object,were randomly divided into treatment group (50 cases) and the control group (50 cases). Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) were used to evaluate severity entrants of anxiety and depression of the patients. The changes of anxiety depression rating scale,angina pectoris,arrhythmia and acute myocardial infarction occurred situation before and after treatment in patients,drug safety,etc were observed.Results After Escitalopram joint Tandospirone treating in older women patients with coronary heart disease complicating anxiety disorder combined depression disorder based on routine treatment,the HAMA scores reducion was significantly higher in treatment group (14.07±5.39) than that in control group (7.19±4.81 P<0.05) The HAMD scores reducion were significantly higher in treatment group (14.59±6.76)than that in control group (7.28±6.27 P<0.05). The recurrence rate of coronary heart disease angina adverse events including angina pectoris,acute myocardial infarction,severe arrhythmia were 4.54%,0%,6.82% respectively in treatment group,they were 16.28%,2.33%,18.60% in control group,the coronary heart disease events of the treatment group were significantly lower than those in control group (P<0.05),and the drug safety was better.Conclusions Additional treatment of Escitalopram joint Tandospirone in older women patients with coronary heart disease complicating anxiety disorder combined depression disorder,may obtain a better benefit,improve the recovery.