AimTo explore the incidence and affecting factors of left ventricular hypertrophy (LVH) in chronic kidney disease (CKD) 3～5 patients.Methods270 CKD 3～5 patients were enrolled from department of nephrology, the 3rd hospital of Sun Yat-Sen University in this study from 2010 to 2012.Ambulatory blood pressure, clinical blood pressure, cardiac ultrasonography, proteinuria, and other clinical data were collected.Results46.67% CKD patients had LVH, in which male accounted for 39.74% and female accounted for 55.46%.Female group had more LVH patients than male group (P<0.05).There were 25.0% CKD 3 patients, 44.9% CKD 4 patients and 53.6% CKD 5 patients with LVH respectively, which had significant difference among the three groups(P<0.05).LVH group had higher intact parathyroid hormone (iPTH), body mass index (BMI), phosphorus, serum creatinine (SCr), left ventricular mass index (LVMI), pulse, PP, left ventricular end diastolic dimension (LVDd), left ventricular posterior wall thickness (LVPWT), interventricular septal thickness (IVST), and higher clinic systolic blood pressure (SBP), ambulatory SBP and diastolic blood pressure (DBP), day and night SBP and DBP(P<0.05), but had lower estimated glomerular filtration rate (eGFR), hemoglobin (HGB), calcium (Ca) and ejection fraction (EF) value(P<0.05) compared with non LVH group.Multivariate linear analysis indicated that BMI, iPTH and night SBP were independently associated with LVMI.