Aim To summarize the clinical manifestation and the characteristic of coronary angiography of patients with the honeycomb-like or lotus root-like coronary thrombotic lesions, and to explore the experiences and technique of percutaneous coronary intervention （PCI） for the peculiar coronary lesions. Methods We retrospectively analyzed the data from 10 patients with the honeycomb-like or lotus root-like coronary thrombotic lesions. Results 7 of 10 patients with the honeycomb-like or lotus root-like coronary thrombotic lesions suffered from myocardial infarction more than one month（one month～20 years）. The honeycomb-like or lotus root-like coronary thrombotic lesions were found in right coronary arteries in 7 of 10 patients, and in left anterior descending coronary artery in the other 3 patients. Successful PCI was performed in 7 of 8 patients with the evidence of myocardial ischemia. Conclusion The honeycomb-like or lotus root-like coronary lesions resulting from recanalized thrombus after myocardial infarction are common in right coronary artery. The hydrophilic-guide wires are often the preferred choice of PCI for the peculiar coronary thrombotic lesions.