Macrophages plays an important role in atherosclerotic plaque development, progression and destabilization, then reduction of macrophages in plaque promotes the regression of atherosclerotic plaques. Emigration of macrophages from plaques is one approach for reduction of macrophages in plaques, so this paper reviewed activated receptor CCR7, inhibited receptors UNC5b and PlexinD1, oxidative stress in egression of macrophage from plaque.