Aim To determine the predictive value of d-dimer （DD） and fibrinogen （FIB） for risk-stratification of patients with transient ischemic attack （TIA）. Methods We designed a prospective study.132 patients with acute TIA in hospitalization were enrolled.These patients were divided into low （0～3 points,46 patients）,medium （4～5 points,70 patients） and high （6～7 points,16 patients） risk groups according to their ABCD² scores.DD and FIB were measured.The primary outcome measure was a composite endpoint event,which was consisted of stroke or death within 90 days,or ≥50% stenosis in a artery association with clinical symptoms,or cardioembolic source warranting anticoagulation. Results According to the results of the composite endpoint,all patients were divided into positive group （34 patients） and negative group （98 patients）.FIB were higher in positive group compared to negative group （P<0.05）.There was no relationship between DD and composite endpoint （P>0.05）.FIB were elevated in patients with ≥50% stenosis （P<0.05）.ABCD² score ≥4 （moderate risk: RR＝2.18,95%CI 1.26～3.61,P＝0.008 high risk group: RR＝3.43,95%CI 1.91～6.39,P＝0.001） and FIB ≥3.5 g/L （RR＝2.81,95%CI 1.05～6.32,P＝0.044） were significantly associated with the composite endpoint. Conclusion FIB is an independent risk factor for TIA,and the combination of FIB and the ABCD² score can improve the ability to predict stroke and death within 90 days after TIA.