Aim To explore the post-discharge death of patients with acute ST-segment elevation myocardial infarction(STEMI) after emergency percutaneous coronary intervention(PCI) and the risk factors affecting post-discharge death. Methods 413 patients with STEMI who underwent PCI were collected to investigate clinical data and follow-up results. The follow-up endpoint was all-cause death after discharge. The deaths of patients were recorded after discharged from the hospital, and the related factors affecting post-discharge death were analyzed. Results The average follow-up time was 26.38±14.21 months. There were 27 patients died and 43 patients lost to follow up(10.4%) during the follow-up period. COX proportional hazards regression model showed that age≥60 years(HR＝8.927, P＝0.037) and Killip class＞Ⅰ(HR＝2.546, P＝0.034) were associated with post-discharge death after PCI in STEMI patients. The cumulative mortalities of 1-year, 2-year, 3-year and 4-year in all follow-up patients were 4.9%, 7.3%, 7.9% and 10.1% respectively. The cumulative mortalities of 1-year, 2-year, 3-year and 4-year in age≥60 years group were significantly higher than those in age＜60 years group(7.7% vs 0.7%, 11.6% vs 0.7%, 12.7% vs 0.7%, 16.0% vs 0.7%, all P＜0.001).The cumulative mortalities of 1-year, 2-year, 3-year and 4-year in Killip class＞Ⅰ group were significantly higher than those in Killip class Ⅰ group(12.7% vs 2.5%, 19.8% vs 3.5%, 19.8% vs 4.4%, 26.5% vs 5.5%, all P＜0.001). Conclusions The post-discharge mortality rate of patients with STEMI after PCI is still higher. Age≥60 years and Killip class＞Ⅰ are independent risk factors of post-discharge death after PCI in STEMI patients.