Aim To investigate the relationship among monocyte/high density lipoprotein cholesterol ratio and inflammatory adipocytokines with the severity of coronary artery stenosis. And then the diagnostic value of the new markers on coronary artery disease (CAD) was analyzed. Methods A total of 168 inpatients with CAD and a control group of 74 cases without significant coronary artery stenosis were consecutively enrolled from January 2017 to August 2017 in the division of cardiology in our hospital. All the demographic and clinical data of the subjects were collected by the physicians and master degree candidates in the division of cardiology. The concentrations of plasma inflammatory adipocytokines were measured by ELISA. Results Monocyte/high density lipoprotein cholesterol ratio, plasma levels of PTX3, RBP4, GAL-3 and PAI-1 were higher, while the plasma levels of IL-37, NTN1 and ADP were lower in CAD group than those in the control group. Monocyte/high density lipoprotein cholesterol ratio was significantly correlated with the coronary Gensini score and inflammatory adipocytokines. In addition, the area under the receiver operating characteristic curve (ROC-AUC) of monocyte/high density lipoprotein cholesterol ratio was 0.676. Conclusion Monocyte/high density lipoprotein cholesterol ratio and the adipocytokines may be enlightening diagnostic markers of CAD, which also will be helpful in assessing the severity of coronary artery stenosis in clinical practice.