Coronary artery calcification is a common pathological feature in many diseases, such as coronary atherosclerosis, diabetic angiopathy and chronic kidney disease. Statins are commonly used in patients with coronary atherosclerotic heart disease and dyslipidemia. Previous studies have shown that statins may inhibit coronary artery calcification, but recent studies have suggested the opposite. In view of the disputes over the relationship between statins and coronary artery calcification, this article analyzes the mechanism of coronary artery calcification, the relationship between statins and coronary artery calcification, and the reasons of contradiction between them.