H型高血压患者颈动脉粥样硬化相关危险因素分析
DOI:
作者:
作者单位:

(1.无锡市第三人民医院心内科,江苏省无锡市 214000;2.苏州大学附属第一医院心内科,江苏省苏州市 215000 )

作者简介:

尚晖,硕士研究生,住院医师, 研究方向为高血压病,E-mail为shanghuismmu@163.com。

通讯作者:

基金项目:


Risk factors of carotid atheroscleosis in patients with H-type hypertension
Author:
Affiliation:

1.Department of Cardiology, the Third People's Hospital of Wuxi, Wuxi, Jiangsu 214000, China;2.Department of Cardiology, the First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu 215000, China)

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
    摘要:

    目的 探讨H型高血压患者发生颈动脉粥样硬化的相关危险因素。方法 纳入原发性高血压患者240例,根据血浆同型半胱氨酸(Hcy)水平是否≥10 μmol/L,分为H型高血压组(H组)118例和单纯高血压组(单纯组)122例,比较两组患者一般情况、生化指标、颈动脉血管壁内膜-中膜厚度(IMT)和颈动脉斑块数量。采用多因素Logistic回归分析H组患者发生颈动脉粥样硬化的相关危险因素。结果 H型高血压患者在性别构成、冠心病病史、脑卒中病史、收缩压、脉压、Hcy、低密度脂蛋白(LDLC)、尿素氮(BUN)和肌酐(Cr)、尿酸(UA)、劲动脉斑块形成、斑块数、IMT、斑块数≥3个、50%狭窄的检出率等方面均高于单纯组(P<0.05)。Logistic多元回归分析显示,H型高血压患者颈动脉IMT与高龄、吸烟和高LDLC显著相关(P<0.05),危险度分别为1.282(95%CI 1.133~1.451)、6.663(95%CI 1.200~20.669)和4.301(95%CI 1.199~15.434);斑块形成与高龄、男性和超重显著相关(P<0.05),危险度分别为1.150(95%CI 1.069~1.238)、3.496(95%CI 1.353~9.033)和1.244(95%CI 1.014~1.526)。结论 H型高血压患者颈动脉IMT与高龄、吸烟和高LDLC显著相关;斑块形成则与高龄、男性和超重显著相关。

    Abstract:

    Aim To investigate the carotid atherosclerosis risk factors of H-type hypertension. Methods A total of 240 hospitalized patients with primary hypertension from january 2017 to january 2018 were selected. According to the plasma homocysteine(Hcy) level, participators were divided into H-type hypertenion group(H-group, plasma Hcy>10 μmol/L)with 118 cases and simple group(plasma Hcy≤10 μmol/L) with 122 cases. Patients' general information, biochemical index, carotid intima-media thickness(IMT), carotid atherosclerotic plaques and the condition of carotid stenosis, were compared between the two groups. Multivariate Logistic regression was used to analyze the risk factors of carotid atherosclerosis in H-group patients. Results Male composition, coronary heart disease history, stroke history, mean systolic blood pressure , pulse pressure, plasma Hcy, low density liporotein cholesterol(LDLC), urea nitrogen(BUN), creatinine(Cr) and uric acid(UA) levels, the detection rate of the carotid IMT, plaque formation, IMT, the plaque number≥3, carotid stenosis >50% in H group were significantly different from simple group(P<0.05). Multivariate Logistic regression analysis demonstrated that aged, smoking history, high LDL were significantly associated with carotid IMT in H-type hypertension patients, with OR values 1.282(95%CI 1.133~1.451), 663(95%CI 1.200~ 20.669), 4.301(95%CI 1.199~15.434) respectively. Moreover, aged, overweight, high LDL with OR values 1.150(95% CI 1.069~1.238), 3.496(95%CI 1.353~9.033), 1.244(95%CI 1.014~1.526)were significantly associated with plaque formation. Conclusions Aged, smoking history, high LDL were significantly associated with carotid IMT of H-type hypertension patients. Aged, overweight, high LDL had significant effect on the progression of plaque formation.

    参考文献
    相似文献
    引证文献
引用本文

尚晖,李勋. H型高血压患者颈动脉粥样硬化相关危险因素分析[J].中国动脉硬化杂志,2019,27(11):969~974, 984.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
历史
  • 收稿日期:2019-03-08
  • 最后修改日期:2019-05-13
  • 录用日期:
  • 在线发布日期: 2019-12-18