Coronary heart disease (CHD) is a common complex disease caused by the interaction of multiple genes and environmental factors. In recent years, it has been found that CHD is closely related to epigenetic modification represented by DNA methylation. Epigenetics studies the influence of environment rather than genetic sequence itself on gene expression, which coincides with the overall concept of traditional Chinese medicine (TCM) and the theory of correspondence between nature and man. TCM follows the overall concept, pays attention to the influence of external factors such as environment on the human body, and achieves the internal balance of the body through TCM treatment. In recent years, TCM researchers have made great progress in the research on the DNA methylation connotation of TCM syndromes of CHD and the methylation mechanism of TCM intervention in CHD. The author combed the relevant literature and summarized it in order to provide reference for future research.