We reported the effects of gypenosides (GPS) on serum levels of nitric oxide(NO),lipid peroxidation(LPO)and superoxide dismudase(SOD)in atherosclerotic rabbit induced by high cholesterol diet.The results showed that GPS 60 mg·d-1 fed in company with 1% cholesterol for 8 weeks and GPS 120 mg·d-1 orally administrated for 4 weeks after development of aortic lesion could significantly protect the activity of NO and SOD,decrease the LPO content as well as lower the serum levels of total cholesterol and triglyceride.