To investigate pharmacological mechanism of Kechuan inhalation(KCI),the effcts of Kechuan inhalation on blood-fat,liver-fat and blood-sugar in the rats and the mice were studied in this paper. The results showed that after inhaling drug-gas of Kechuan inhalation,the level of serum triglyceride and total cholesterol were decreased considerably in mice,at the same time,the increase of triglyceride induced by high lipid diet in liver of mice were inhibited significantly.In addition,the level fatty liver of hepatic homogenization triglyceride in rats with induced by DL-ethionine was lowered obviously by inhaling drug-gas of Kechuan inhalation. These results suggest that Kechuan inhalation maybe a role of reducing blood-fat and pretecting liver.