Low dose of the statin lipid regulating drugs,namely 10 mg daily dose of lovastatin of 5 daily dose of simvastatin was given to 28 cases with primary hypercholesterolmia.The results showed after 2 weeks and 4 weeks of treatment the levels of serum total cholesterol(TC) decreased 21.4%(P< 0.05) and 30.4%(P< 05),respectively; and the levels of lowdensi ty lipoprotein cholesterol (LDLC) decreased 36.3% (P< 0.05) and 52.9% (P<0. 05) respectively,and high-den sity lipoprotein cholesterol (HDLC) increased 15.5%(P <0. 05) and 28.3%(P<0. 05) ,respectively. Although the levels of triglyceride (TG) also decreased greatly after treatment but didn’t differ from the basic value significantly,only epigastric distress occured in one patient. The data demonstrated the low dose of statin lipid regulating drugs could decrease TC concentration and increase HDLC concentration remarkably within a period of short time and the incidence of side effects was very low. It is worthwhile to recommend spread use clinically.