Aim To examine the effect of sole or combining treatment of pravachol and inositoli nicotinatis on blood lipid in patients with hyperlipidemia.Methods 72 cases with hyperlipidemia were divided into pravachol group, inositoli nicotinatis group and combining treatment group. Treatment period lasted for 4 weeks,blood lipid parameters were measured before and after treatment.Results After treatment pravachol significant cend the levels of TC and LDLC, doesn't descend TG (TC: 7.0 ±1.4vs 5.9mmol/L, p<0. 05; TG: 2. 7±1.2vs 2.5±1.0 mmol/L, p<0.05; LDLC: 4.6 ±1.3vs 3.6±1.2mmol/L, p<0.05), inositoli nicotinatis significant reduce TG, doesn't descend TC,LDLC (TC: 7.0±1.4vs 6.4±1.5mmol/L, PRO.05; TG: 2.7±1.2vs 2.1±0.9mmol/L, p<0.05; LDLC: 4.6±1.2vs 4.3±1.3mmol/L, p<0.05).Decreased or increased magnitude of blood lipid composition in combining group were greater than those in pravachol group and inositoli nicotinatis group (TG:- 27.3%, -15. 6% and -7.5%, p<0. 05; TG:- 31.9%,-7.l% and -22.8%, p<0.05; HDL: +11.2%, +l.7% and +4.4%,p<0. 05). 39 cases that sole treatment was not effective received combining treatment for another 4 weeks, blood lipid composition have furture changed (TG:6.5±1.4 vs 4.5±1. 3mmol/L,p<0.01; TG: 2.6±1. 2 vs 1. 9±1. 1 mmol/L,p<0. 01; HDL: 1. 16±0. 22 vs 1.27f±21 mmol/L,p<0.05).Conclusion These data suggest that combining pravachol with inositoli nicotinatis treatment can enhance the reducing blood lipid effect, improving blood lipid composition.