Aim To investigate whether basic fibroblast growthfactor (bFGF) , epidermal growth factor (EGF) , tu-mor necrosis factor-a (TNF-a ), and granulocyte-macrophage colony stimulating factor (GM-CSF) haveeffect on the binding of scavenger receptor of vascularsmooth muscle cells(VSMC) and oxidized low densitylipoprotein (ox-LDL) .Methods Antibody against ox-LDL was prepared us-ing immunizing guinea pig with ox-LDL which wasmade by means of copper oxidization. Smooth musclecells were collected from the culture of calf aorta medi-a. The binding activity between scavenger receptorand ox-LDL was analyzed using cell BA-ELSA.Results The binding activity of scavenger receptorand ox-LDL was 4. 8 ±4. 0 g/L. The activity in-creased 3～3. 5 fold by adding bFGF , EGF , TNF-a (P<0. 05) ; Adding GM-CSF had no significant effect onthe binding.Conclusion bFGF, EGF, and TNF may play role inregulation of scavenger receptor activity of SMCs.