im The protective effects of human urinarykallidinogenase (SK-827 3 on myocardial ischemia/reperfusion (I/R) injury were investigated in the isolat-ed rabbit hearts.Methods Coronary effluent myoglubin (Mg) andlactate dehydrogenase (LDH ) content, myocardialmalondialdehyde (MDA ) andATP level were assayedby biochemical technique.Results in SK-827 group ,coronary flow increased ,cellular Mg and LDH leakage decreased, myocardialMDA content decreased and ATP content increased ascompared with I/R group.Conclusion SK-827 has an appliance in clinical my-ocardial I/R injury therapy.