Aim To observe the effect of liver regulating and turbid removing Chinese medicine formular to apolipoprotein content in blood and lipoprotein receptor in membrane of hepatocyte and research the principle of preventing and curing atherosclerosis. Methods The rabbits were fed with heavy dosage of cholesterol in order to obtain the mould of atherosclerosis by assaying the content of apolipoprotein AI and apolipoprotein B in blood. In addition, the hepatocyte of rat was cultured in vitro by adding ox LDL into the culture medium, and the effect of lipoprotein receptor and the regulating function of Chinese medcine formular related with given in different ways by means of hybridization in situ were observed. Results and Conclusions Liver regulating and turbid removing Chinese medicine formular can increase effectively the content of apolipoprotein AI, decrease that of apolipoprotein B and have a good regulating function about the lipoprotein receptor or passway. Consequently, liver regulating and turbid removing Chinese medicine formular can regulate the factors related with lipid metabolism, thus effectively prevent the formation and progress of hyperlipemia.