Aim To observe the inhibition effect of Tongxinluo on inflammation and intima proliferation response induced by interleukin-1β(IL-1β) in small swine,and to investigate its action mechanism. Methods Chinese mini-swine were randomly divided into three groups,control group,model group and Tongxinluo group.The control group and model group were fed with special diet;the Tongxinluo group were fed with special diet and Tongxinluo [1 g/(kg·d)].After 2 weeks' feeding,chest operation was done by isolation of left-anterior descending banch and circumflex branch proximate.Coronary artery membranna externa in swine was packed by paper towel absorbing saline agarose particle suspension in control group.But in model group and Tongxinluo group,coronary artery membranna externa was packed by paper towel absorbing IL-1β(2.5 μg)agarose particle suspension.After 2 weeks,lumens narrow was observed by coronary arteriogramphy.The vascular section in the treated site was taken out to be examined by pathology and the monocyte chemoattractant protein-1(MCP-1),P-selection,E-selection, intercell adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule-1(VCAM-1) mRNA expression was measured by reverse transcription polymerase chain reaction analysis(RT-PCR). Results The coronary arteriogramphy showed that atherosclerotic changes and luminal stricture in local blood vessel in Tongxinluo group was dscreased compared with control group.The pathological examination showed that the degree of luminal stricture,the macrophage accumulation and endometrial hyperplasia in Tongxinluo group was obviously lighter than that of model group.The expression of mRNA of MCP-1,P-selection,E-selection,ICAM-1 and VCAM-1 in Tongxinluo group were decreased. Conclusions Tongxinluo could inhibit coronary artery early inflammation response and intima proliferation induced by interleukin-1β by inhibiting the mRNA expression of MCP-1,P-selection,E-selection, ICAM-1 and VCAM-1.