丙丁酚可干预小鼠动脉粥样硬化病变并调节B类I型清道夫受体的表达
DOI:
作者:
作者单位:

作者简介:

通讯作者:

基金项目:

国家自然科学基金(30570958);;湖南省卫生厅课题(B2006-098)资助


The Dynamic Changes of Serum Von Willebrand Factor and High Sensitivity C-Reactive Protein in Renovascular Hypertensive Rats
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
    摘要:

    目的研究丙丁酚对高脂高胆固醇饲养的载脂蛋白E基因敲除小鼠和C57BL6/J小鼠血脂及动脉粥样硬化病变的影响,以及肝脏B类I型清道夫受体和PPARγ表达的变化。方法分别随机将20只载脂蛋白E-/-小鼠和20只C57BL6/J小鼠分为载脂蛋白E-/-高脂组和载脂蛋白E-/-高脂+0.5%丙丁酚组。动物喂养12周,摘眼球取血,采用酶比色法检测剂盒测定小鼠血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL胆固醇)和低密度脂蛋白胆固醇(LDL胆固醇)的....

    Abstract:

    Aim To study dynamic changes of serum von Willebrand factor(vWF) and high sensitivity C-reactive protein(hs-CRP) in renovascular hypertensive rats,and to investigate the effect of vWF and hs-CRP in the deployment of atherosclerosis(As) and stroke. Methods vWF and hs-CRP were measured with enzyme linked immunoabsorbent assay(ELISA),the results were compared with the control group and sham-opetated group. Results At the end of 4,8,12 weeks after the operation,the concenrations of serum vWF and hs-CRP were significantly increased compared with the control group and sham-operated group;the blood pressure were increasing in the hypertensive group after the operation,and the concenrations of serum vWF and hs-CRP were increasing simultaneously. Conclusion When the blood pressure were increasing,the concenrations of serum vWF and hs-CRP were increasing simultaneously;vWF and hs-CRP played vital roles in As.The high concenrations of serum vWF and hs-CRP might be the risk factors to ischemic stroke.

    参考文献
    相似文献
    引证文献
引用本文

尹小波,莫中成,叶延平,曾德星,冯惊涛,李霞,郭鹏程,曾颖,易光辉.丙丁酚可干预小鼠动脉粥样硬化病变并调节B类I型清道夫受体的表达[J].中国动脉硬化杂志,2007,15(7):569.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
历史
  • 收稿日期:2006-12-04
  • 最后修改日期:2007-06-02
  • 录用日期:
  • 在线发布日期: