Aim To investigate the effect of Helicobacter pylori (Hp) infection on plasma lipid and high sensitive C reactive protein (hs-CRP) levels in patients with coronary heart disease (CHD). Methods 159 CHD patients were recruited for this study. And plasma fibrinogen, plasma lipid, plasma urine acid and hs-CRP were examined in all subjects. Expiratory test were executed in all subjects. All subjects were divided into negative infection group, slight infection group and serious infection group. Results In patients with Hp infection, plasma hs-CRP, total cholesterol (TC) and low density lipoprotein cholesterol (LDLC) were significantly higher, but triglyceride (TG) level was lower, compared with negative infection group (P<0.05); Plasma hs-CRP was significantly higher in serious infection group than in slight infection group (P<0.05). Conclusion Hp infection may increase vascular inflammatory reaction through lipid metabolic disturbance. There maybe have higher cardiovascular events rates in CHD patients with Hp infection.