Aim To investigate the relationship between sex hormone levels and coronary heart disease (CHD) in diabetic men. Methods The serum testosterone (T) and sex hormone binding globulin (SHBG), lipids, glucouse were assayed. Blood pressure, body mass index (BMI) were studied in 102 cases of diabetic men, inclnding 58 cases with CHD, and 44 cases without CHD (NCHD). Results Serum levels T and SHBG were decreased significantly, the differences of BP, lipids, BMI remained statistically significant, but serum glucose had no statistically significant difference in CHD compared with fast NCHD. Conclusion Diabetic men with CHD have significant lower levels of T and SHBG than without CHD. Lower levels of sex hormone is an important risk factor of CHD in diabetic men.