Aim To study the effect of united therapy of probucol(P) and clopidogrel(Anti-thrombosis,A) and atorvastatin(statin,S) on rabbit atherogenesis. Methods 36 rabbits were randomized into four groups.The one group did not receive treatments and served as control group.Atherosclerosis was induced in the aorta arteries of rabbits by atherogenic diet in the next groups for 6 weeks.Then, animals were randomized to receive either no treatment or therapy.One group of treatment were received atorvastatin 2.5 mg/(kg·d),and the other accepted probucol(1.0 g/d) and clopidogrel 5 mg/(kg·d) and atorvastatin 2.5 mg/(kg·d) and killed after 4 weeks. Results Atorvastatin and united therapy induced a significant reduction in serum lipids and in lesion size,also were the area and thickness in neointima.Arterial macrophage infiltration was abolished by the treatment.Notedly,there was a more evident effect in united therapy than Atorvastatin in anti-atherosclerosis. Conclusions Atorvastatin and united therapy diminish the plaque lesion and neointimal inflammation in rabbit atherosclerosis model,and the effect of united therapy was more than atorvastatin.This could contribute to the more stabilization of the atherosclerotic plaque,and may be a more meaning additional prediction for the reduction of acute ischemic events in patients treated with united therapy.