Aim To investigate the relationship of carotid artery segments-specific intima-media thickness(IMT),plaque summary score,brachial artery flow-media dilatation and extent of coronary artery atherosclerosis. Methods 31 consecutive eligible patients were divided into three groups with low,medium and high score.Intima-media thickness of the right and left carotid artery(the common carotid artery,internal carotid artery,bifurcation) were measured with external vascular ultrasound,the brachial artery flow-mediated dilatation of all subjects was measured noninvasively by the same ultrasound machine. Results A significant positive correlation between the intima-media thickness of various segments carotid artery and the extent of coronary atherosclerosis was found in all of the subjects,and a better correlation could be got between the intima-media thickness of bifurcation and the extent of coronary atherosclerosis(r=0.679,P<0.01).There was a significant positive correlation between plaque Crouse summary score and the extent of coronary atherosclerosis in all of the subjects,and it was easy formate plaque at the bifurcation(P<0.05).A significant negative correlation among percent FMD and the extent of coronary atherosclerosis was found in all of the subjects(r=-0.646,P<0.01).Nitroglycerin-induced endothelium-independent vasodilation among the three groups showed the trend of gradually weakening,but did not reach statistical significance(P>0.05). Conclusion Carotid IMT and brachial artery FMD may be a better reflection of the determination of coronary artery sclerosis.