Aim To investigate the curative effect of tanshinone ⅡA united with simvastatin and diuretic treating the legs atheromatosis with groin lymphadenectasis and oedema legs. Methods 42 patients which had lymphadenectasis and oedema caused by atherosclerosis were collected.The total patients were assigned to two groups.The treatment group was cured by tanshinone ⅡA united with simvastatin and diuretic;the control group was cured by simvastatin united with diuretic;the course of treatment was 15 days.Each group's curative effect was evaluated. Results The treatment group's total effective rate was 95.24%,the control group's total effective rate was 10.53%.The difference was notable. Conclusion Tanshinone ⅡA was more effective to preventing and treating atherosclerosis oedema legs,and the side effect was little.