GALNT2 is a key member of polypeptide:N-acetylgalactosaminyltransferase family (GalNAc-Ts), and recent GWAS based epidemiological study reveal that its polymorphism can interrupt HDLC and TG levels in blood, and is significantly associated with cardiovascular disease.GALNT2 participates in the first step of O-linked glycosylation and is regarded as a cardiovascular disease susceptible gene recently.Therefore, its function and genetic difference as well as the relationship with cardiovascular disease will become a hot research point in the future.This review will focus on the recent advances in research of its biological characteristics, functions, gene polymorphisms and relationship with lipids levels and cardiovascular disease.