AimTo investigate the effect of cytotoxin associated gene A(+) Helicobacter pylori eradication on vascular endothelial function and arterial elasticity in patients with essential hypertension.Methods62 essential hypertension patients infected with cytotoxin associated gene A(+) Helicobacter pylori (eradication therapy group)and 62 essential hypertension patients without infecting with Helicobacter pylori (control group) were recruited into the study.The patients in eradication therapy group were adminstrated with eradication therapy for a week to Helicobacter pylori, however, the patients in control group were adminstrated with placebo for a week on the basis of general treatment.The levels of plasma lipids, circulating endothelial- derived microparticles and arterial elasticity were performed at the beginning and the end of study in all subjects.The follow-up period was 6 months.ResultsIn comparison with the levels at beginning, the levels of plasma total cholesterol and circulating endothelial-derived microparticles were significantly decreased and C2 significantly increased in erdication therapy group at the end of study(P<0.05).ConclusionHelicobacter pylori eradication might improve the vascular endothelial function and arterial elasticity in essential hypertension patients infected with cytotoxin associated gene A(+) Helicobacter pylori.