Angioplasty treatment is one of the main methods for narrow or occlusive vascular disease, but restenosis affects the long-term effect.Prevent vascular restenosis has been an important subject in cardiovascular diseases. Ultrasound-targeted microbubble destruction can deliver gene or drug to the points of interest in the body, which can enhance the concentration of the gene or drug, enhance efficacy cure effects, and provide a new method for restenosis.In this review, we will introduce the theory of gene or drug therapy mediated by ultrasound-targeted microbubble destruction, and its prospects in vascular restenosis.