Aim To investigate whether peroxisome proliferator activated receptors gamma （PPARγ） activator GW1929 regulates suppressors of cytokine signaling-1 （SOCS1） and SOCS3 expression as well as production of tumor necrosis factorα （TNF-α）, interleukin-10 （IL-10）, and interferon-γ （IFN-γ） in macrophages induced by oxidized low density lipoprotein （ox-LDL）. Methods Real-time PCR were used to analyze SOCS1 and SOCS3 mRNA expression after the mouse peritoneal macrophages were pretreated with ox-LDL （50 mg/L） and GW1929 （20 μmol/L） for 4 h. Western blot were used to analyze SOCS1 and SOCS3 protein expression after the mouse peritoneal macrophages were pretreated with ox-LDL （50 mg/L） and GW1929 （20 μmol/L） for 6 h. The concentrations of TNF-α, IL-10 and IFN-γ in the culture supernatant were detected after macrophages were pretreated with ox-LDL and GW1929 for 24 h by enzyme linked immunosorbent assay （ELISA）. Results The concentrations of TNF-α, IL-10 and IFN-γ and ratios of TNF-α/IL-10，IFN-γ/IL-10 in ox-LDL group were higher than those in control and GW1929 group obviously, but the concentrations of the above factors in ox-LDL +GW1929 group were lower than those in ox-LDL group apparently. The expressions of SOCS1 at mRNA and protein level in ox-LDL group were higher than those in control and GW1929 group obviously,and SOCS1 expr-