Atherosclerotic cerebral and cardiovascular diseases are the primary chronic inflammatory diseases which are impairing the human health. Abnormal lipid metabolism is considered as the putative major risk factor of atherosclerosis. In 2001, researchers from Columbia University found that phospholipid transfer protein （PLTP） could affect lipoprotein metabolism and then alternate atherosclerotic susceptibility, thus initiate the PLTP research as a hot topic for decades.