Aim To explore the expression of matrixmetallop roteinase-9 （MMP-9） and tissue inhibitor of metallop roteinase-1 （TIMP-1） in different treatment for patients with Kawasaki disease （KD）, and discuss the protective effect of Tanshinone ⅡA （TanⅡA） on the coronary artery 1esion （CAL） with KD. Methods Forty-eight Kawasaki patients including twenty-eight no coronary artery 1esion （NCAL） and twenty CAL, and twenty-four healthy children as controls were recruited into the study. The patients with Kawasaki disease were randomly divided into two groups: TanⅡA treatment group and contrast treatment group （including fourteen NCAL and ten CAL patients in each group）. The serum MMP-9 and TIMP-1 levels were detected by ELISE. The MMP-9 and TIMP-1 mRNA expression were detected by real-time fluorescence quantification PCR （qRT-PCR） in the peripheral blood mononuclear cells （PBMC）. Results Compared with the normal group, the expression of MMP-9 and TIMP-1 were increased before treatment, and decreased after treatment of five to seven days both at the mRNA and protien in the KD group （P<0.05）. However, the KD patients