Foxp3表达与老年颈动脉粥样硬化的关系
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Relationship Between Expression of Foxp3 and Carotid Atherosclerosis in Elderly Patients
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    摘要:

    目的 探讨老年颈动脉粥样硬化与外周血叉头翼状螺旋转录因子p3(Foxp3)表达以及高敏C反应蛋白(hs-CRP)之间的关系。方法 对66例老年颈动脉粥样硬化患者和51例健康对照者分别利用流式细胞仪检测外周血Foxp3,速率散射比浊法检测hs-CRP。结果 老年颈动脉粥样硬化患者外周血CD4CD25Foxp3调节性T淋巴细胞显著减少,经瑞舒伐他汀钙治疗后较治疗前明显增加;颈动脉粥样硬化患者血清hs-CRP明显高于对照组,有颈动脉斑块的患者血清hs-CRP显著高于颈动脉内中膜增厚患者;将CD4CD25Foxp3与hs-CRP进行相关性分析,两者之间呈负相关。结论 老年颈动脉粥样硬化与外周血Foxp3表达、hs-CRP密切相关。外周血Foxp3表达、hs-CRP在老年人颈动脉粥样硬化、斑块形成的发生发展中起着重要的作用,控制这些危险因素有益于控制和减少脑卒中的发生。

    Abstract:

    Aim To investigate the relationship between carotid atherosclerosis in elderly patients and the expression of forkhead/winged helix transcription factor p3 (Foxp3), and high sensitivity C reactive protein (hs-CRP) in peripheral blood. Methods 66 cases of elderly patients with carotid atherosclerosis and 51 healthy controls were detected by flow cytometry of peripheral blood Foxp3, nephelometry hair testing hs-CPR. Results Perpheral CD4+CD25Foxp3 regulatory T lymphocytes in elderly patients with carotid atherosclerosis decreased significantly and increased after rosuvatatin treatment, significantly higher than that before treatment serum hs-CRP in patients with carotid atherosclerosis was significantly higher than that of the control group, hs-CRP in patients with carotid artery plaque were significantly higher than that in patients with carotid artery intima-media thickness Foxp3 was correlated negatively with hs-CRP. Conclusions Carotid atherosclerosis in the elderly patients are closely related with peripheral blood expression of Foxp3 and hs-CRP. The peripheral blood Foxp3 and hs-CRP play an important role in the occurrence and development of plaque formation in carotid atherosclerosis, and the control of these risk factors is beneficial to controling and reducing the occurrence of apoplexy.

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李 峰,马金栋,高 颖,刘丰基. Foxp3表达与老年颈动脉粥样硬化的关系[J].中国动脉硬化杂志,2014,22(06):617~621.

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  • 收稿日期:2013-07-01
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