Aim To study the effect of atorvastatin combined with brisk walking on atherosclerotic plaques reversal. Methods 120 atherosclerotic patients were divided into statin group and combined group. Carotid atherosclerotic plaque area, carotid intima-media thickness and stable plaque rate were used to evaluate plaque reversal effect. Statin group was given atorvastatin calcium tablets 20 mg/d (Beijing Ale) orally. The combined group took a quick walk (4～5 days/week) on the basis of atorvastatin calcium tablets 20 mg/d. The follow-up was 2 years. Results The combined group was superior to statin group in reducing TG, TC, LDLC and increasing HDLC. The combined group was superior to statin group in carotid artery plaque IMT, maximum plaque area, plaque number and stable plaque rate. Conclusion The combination of statins and fast aerobic exercise can improve the anti-atherosclerotic effect and reduce the level and function of LDLC, TC and TG, increase the level and function of HDLC, increase the stability of plaque, reverse the plaque effect, and increase the anti-arteriosclerosis as the time prolongs.