In this study,the partially purified low density lipoprotein(LDL) receptor from rabbit liver was used as an antigen, and two monoclonal antibodies were obtained, designated as ZMRE6 and ZMRF7 respectively, both of them can react specifically to rabbit LDL receptor with a high titer and belong to the subgroup of IgG1.Tested with indirect immunofluroscent staining, no cross reaction was found between these two monoclonal antibodies and the cultured human fibroblasts and rhesus endothelial cells,so it is considered that ZMRE6 andZMRF7 have a genus-specificity.