The plasma lipids of 44 type Ⅱ diabetics and 30 healthy persons were compared and analysed, the diabetics were divided into two groups. Group A(n=225) treated with D860 and glucozinc, while Group B only with D860, the course of treatment of both group was one month.The plasma lipids of the diabetics in both group and the healthy persons were measured before and after the treatment respectively. The results showed that:① The triglyceride(TG)and the low-density lipoprotein cholesterol(LDL-C) of the diabetics in both group were distinctly higher than that of the healthy persons, while the high-density lipoprotein cholesterol(HDL-C) was lower than that of healthy controls, ② After the treatment, the HDL-C of Group A was remarkably raised while the TG and LDL-C remarkably reduced, as for Group B, no distinct change was found in HDL-C. This study suggests that Zincic-tonic has an effect to raise the HDL-C level of diabetics who are, at the sametime,in treatment with plasma glucose-lowering medicines.