Compared with giving native low density lipoprotein(LDL) intravenously,scavenger receptor(SR)mRNA levels in liver and spleen of the mice given mildly modified LDL(mm-LDL)intravenously increased 2. 0 times (p<0. 05)and 5.9 times(p<0. 01),respectively;and macrophage colony-stimulating factor(MCSF)mRNA levels also increased 3.2 times(p<0. 01) and 3. 0 times p<0. 01) respectively.Giving MCSF intravenously to mice increased SR mRNA levels in liver and spleen by 3. 6 times(p<0. 05) and 3. 0 times (p<0.01),respectively, and showed some dose-effect relationship.It suggests that giving mm-LDL intravenously might directly induce the expression of SR mRNA in liver and spleen,orindirectly stimulate the expression of MCSF,which in turm induces SR mRNA expression,The significance of these phenomena for local atherogenesis is discussed.