Model of the femoral arterial thrombosis was produced in all 20 rabbits by feeding high cholesterol,manipulating with machanical and electrical damage.Urokinase was then given and reocclusion will be observed subsequently,2 h after recanalization,50% of arteries were reoccluded assessed by angiography. Intimal injury,adhered thrombus containing platelet riched mixed cells were confirmed by pathological examination.During the process of thrombosis and reocclusion, platelet aggregetion rate content of plasma thromboxane A2 and activity of plasminogen activator inhibitor weremarkably increased. Whereas the level of prostacyclin and activity of plasminogen activator significantly decreased.Conclusion:rate of thrombus formation is high the ingradient of thrombus and the rate of reocclusion are closed to human coronary disease.The endothelial injury and activation of platelet being the basis of changs of vessel active substance corspond to the characteristic of formation of coronary thrombosis and reocclusion after thrombolysis.Since the method of preparation is easy and feasible,it wiil be a valuable model for studing some new drug in preniting the reocclusion after thromblysis.