Serum lipids, apolipoprotein C(apo C)levels and post-heparin lipoprotein lipase (LPL)and hepatic triglyceride lipase (HTGL)activities were measured in 30 patients with coronary heart disease (CHD),20 hypertriglyceridemic subjects and 20 control subjects.The results showed that the level of serum apo C Ⅱ in CHD1 patients,with serum triglyceride (TG)<1.41 mmol·L-1,had siginficantly lower level compared to control group, which were reduced 14. 8%, while level of serum apo CⅡ in CHD3 patients,with serum TG > 2. 03 mmol·L-1, were increased significantly.The level of serum apo CⅡ in hypertriglyceridemic patients had significantly higher than that in control group and revealed positive correlation with serum TG (r=0. 599, p<0. 01). Compared with controls, LPL activities in CHD groups were decreased markedly (p<0. 001). This indicates that it may be important significance clinically to measure serum apo C Ⅱ levels for CHD1 group. Increasing apo C Ⅲ levels of hypertriglyceridemic subjects were closely related to the elevated TG levels, the elevation of apo C Ⅲ levels was likely an important cause of forming hypertriglyceridemia. Low levels markedly of LPL activity in CHD patients may be the causes of TG elevated and high density lipoprotein (HDL)decreased,measuring LPL activity may be helpful for diagnosing CHD clinically.