Predictive Value of Troponin T for the Efficacy of Thrombolytic Therapy on Acute Myocardial Infarction
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    Abstract:

    Aim To inquire into the predictive value of serum troponin T(TnT) levels for the therapeutic efficacy in acute myocardial infarction(AMI)treated by thrombolysis.Methods Ninety-two patients with AMI received venously thrombolytic therapy,of whom the infarct related coronary artery(IRA )were reperfused after thrombolysis in 65 cases.The serum TnT levels were detected by using of automatic enzyme-linked immunosorbent assay(ELISA),so as to analyse its characteristics and values for assessing the thrombolytic effects between reperfusion group and noreperfusion's.Results ①The TnT levels initiated rising 4th~8th hour post onset in most of AMI cases,especially earlier for reperfusion group than noreperfusion's(butP>0.05).②The time of arriving to first TnT peak from onset was earlier in reperfusion group than noreperfusion's(17. 78±12.49 h vs 28. 59±15.98 h,P<0.001):and the levels of first TnT peak was a little higher in the former than latter.③The sensitivity, specificity and accuracy of predicting IRA's reperfusion were55.4%, 85.2%and 64.1%respectively for the time reaching the first TnT peak≤12 h; while 76.9%,77.8%and 77.2%respectively for time reaching the first TnT peak≤16h.It was preferable to the CK-MB≤14 h , which was 61.5%,74.1%and 65.2%respectively.Conclusions TnT level s has certain predictive values for IRA reperfusion in AMI after thrombolysis.The sensitivity is higher for the time reaching the first TnT peak≤16h than for CK-MB≤14h.

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XU zhi-Min;HU Da-Yi; CUI Liang; CHEN Mu-Lei;BAO De-Lan; LLAN Gui-Qing; WANG Hong, WANG Lei. Predictive Value of Troponin T for the Efficacy of Thrombolytic Therapy on Acute Myocardial Infarction[J]. Editorial Office of Chinese Journal of Arteriosclerosis,1996,4(3):208.

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