In this studies, we used the plaque grades,the endangia thickness of aorta as Criteria to estimate the atherosclerotic lesiOn grade in Quails and to choose the best modeling time. At the saml time , we have also studied the relationship of the atherosclerosis , cholesterols and the membrane fluidity of peripheral red blood cell.The results showed that the modeling time was the retated the grade of atherosclerosis. It was ideal to model for 16 weeks; Plagues existed on the endangia of the aorta, and the endangia thickened under a microscope. The pathomorphologic changes were similar to that of human being. The membrane fluiditydecreased.The animal's model may be useful in the research of atherosclerosis in human.