Aim: This study evaluated the relation between autoantibody against oxidized low density lipoprotein (ox-LDL) and serum lipids in patients with coronary heart disease (CHD).Methods: The titre of autoantibodies aganist oxLDL and lipid levels in samples of 92 CHD and 105 healthy controls were measured using the enzymelinked immunosorbent assay techinque.Results: The experiment showed that patients withCHD had significant higher levels of autoantibodies than control subjects in regard to anti-ox-LDL IgG(0.45±0. 13 versus 0. 35± 0.09, P<0. 01 ), and the positive rate of autoantibodies was predominant in the subjects with hypertriglyceridemia, hypercholesterolemia,higher LDL cholesterol, and elderly people (≥45), the differences were significant. The titre of autoantibodies against ox-LDL was correlated with total cholesterol (TC) and triglycerides (TG ), Their correlation coefficients were 0. 360 and 0. 408, these were also significantly different.Conclusions: The presence and increase in autoantibodies titers in patients with CHD could be considered a reliable sign of an increased LDL oxidation in vivo,and the titre of autoantibodies could be influenced by the degree of hypercholesterolemia or other factors which influence lipid peroxidation.