Aim: This study was to evaluate the effect of small dose simvastatin on lipid and lipid peroxidation in elderly patients with hyperlipidemia. Methods: Simvastatin (5 mg/day) was administered to 62 elderly patients with hyperlipidemia for 12weeks.Results: Simvastatin caused a significant decrease in serum levels of cholesterol, low density lipoprotein cholesterol(LDLC )and apolipoprotein B (P<0. 001 )at the end of 4, 8 and 12 week therapy. Although triglyceride(TG) level was also significantly reduced at the end of 4 and 8 weeks (P<0. 05), the reduction was not statistically significant at end of 12 weeks.Meanwhile, superoxide dismutase (SOD) rised and malondialdehyde (MDA) fell with simvastatin therapy (P<0.001). Although level of NO-3, a nitric oxide metabolic product, eIevated with the treatment, the change wes not statistically significant. Furthermore, SOD activity was negatively correlated with LDLC, TG and total cholesterol (TC) levels at baseline and also MDA level was positively associated with LDLC and apolipoprotein B levels at the end of treatment (P<0.05) on linear regression analysis.Conclusion: Simvastatin can significantly improve lipid metabolism and diminish lipld peroxidation in the elderly patients with hyperlipidemia.