Aim Whether the mutation of lipoprotein lipase (LPL) gene is associated with coronary heart disease (CHD) or not has been yet knon We study rela-tionship between mutation in intro 6(PvuⅡ) and 8region of LPL gene and CHDMethods We analysed 106 patients in myocardial infarction survivors through a case-control study.The technique of lpoymerase chain reaction (PCR)-re-striction fragment lengths polymorphism(RFLP)was useh to analysed the genotype of LPL gene.23 fac-tors maybe involved in CHD was chosed. Simple and multiple non-conditioned logistic regression analysis demostrated that 6factors were association with CHD.Results The risk factors were diabetes, smoke,hypertension,LPL GENOTYPE pvu ⅡP P and haplo-type H+ P-. While Apo A/B ratio was regarded as a protective factor.Conclusion LPL genotype Pvu P-P- or H+P- oth-er than the standard risks was contribuing to CHD.