Aim To analyse the internal relation between the serum lipid levels and apolipoprotein E genotypes in the aged.Methods The serum lipid levels(TC,TG,LDLC and HDLC)and the apolipoprotein E (apo E)geno-types in 106 the aged were determined with enzymolo-gy and PCR-RFLP respectively.Results There were three alleles of apo E and five different genotypes in 106 the aged.The aged with ε4allele showed higher TC,LDLC and lower TG levels as well as the aged with ε2 allele showed lower LDLC and higher TG levels than the aged with ε3 allele.Conclusion The alleles of apo E have a certain ef-fect on the serum lipid levels in the aged,but the ef-fect may not be as obvious and strong in the aged as in adults.