Aim To analyze the lipid disorders in type II dia-betic patients accompanied with coronary heart disease (CHD)and the important roles of lipid disorder in the development of CHD.Methods The study included 171 cases of healthy control subjects,230 cases of type II diabetic pa-tients,64 cases of CHD patients,and 61 cases of type II diabetic patients accompanied with CHD.All the subjects were examined the serum levels of triglyceride (TG).total cholesterol(TC),low density lipopro-tein-cholesterol(LDLC),high density lipoprotein-cholesterol(HDLC),HDL2C,HDL3C,apolipoprotein A,apolipoprotein B,and lipoprotein(a).Results The serum levels of TG,TC,LDLC,and Apolipoprotein B were significantly higher in type II diabetic patients than in the control subjects.The lipoprotein(a)level seemed to be higher in type II dia-betic patients than in the control subjects.The levels of TG,TC,LDLC,and lipoprotein(a)were higher in CHD patients than in the control subjects.which were similar to the type II diabetic patients.The levels of TG,apolipoprotein B were higher in type II diabetic patients accompanied with CHD than in diabetic or CHD patients separately.The level of HDL3C was lower in type II diabetic patients accompanied with CHD than in diabetic patients.The results of logistic regression showed that the increased levels of TG,lipoprotein(a),and TC were the high risk lipid factors for CHD.Conclusion There existed more severe lipids disor-ders in type II diabetic patients accompanied with CHD.The lipids disorders in type II diabetic pa-tients were atherogenic.The high risk lipid profile for CHD was the increased levels of TG,lipoprotein (a),and TC.